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Monash Institute of Medical Research (MIMR)/Interferome

Background:

The innate immune system is a highly conserved, first line of host defence against infections and other disease stimuli. It initiates inflammatory responses and is important in surveillance of developing cancers. As a result of recent discoveries and an increased understanding of the components of this response, we are now able to better determine its role in diseases, assess human susceptibilities to disease and target therapeutics to this system. A key component of the innate response is the production of hormone-like proteins called interferons (IFNs). These proteins induce several thousand genes which are responsible for constituting each of the many biological effects of interferons – they inhibit viral replication, prevent cell growth and activate cells of the immune response.

The Interferome is a database of IFN regulated genes published in 2009 (Interferome.org; Samarajiwa et al., Nucleic Acids Res. 37, 852). This represents the initial stages in capture and integration of IFN treated microarray datasets, incorporating over 40 published and internally generated microarray datasets. This approach enables identification of interferon regulated gene sets in many biologically diverse high throughput microarray experiments.

Interferome doesn’t currently capture research data directly from researchers.

Summary:

Development of the Interferome system to enable deposition of research data will represent a valuable contribution to Australia’s research data infrastructure within the Immunology and genomics fields. The Interferome approach will address current shortcomings in collaborations and sharing of this valuable data. The availability of the data and their corresponding collection records in the ARDC will enable access to all researchers and facilitate hypothesis generation and novel biological discoveries that would not otherwise be possible.  This will ensure complete analysis and thus full value is achieved from the research data.

Artifacts:

Contacts:

Useful Links:

Access to Research Data:

Research data will begin to become available once the system is released to the research community and they begin loading in their data.  This is expected to take place in Q3 of 2011.




This work is licensed under a Creative Commons Attribution 3.0 Australia License.

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